Endocrine Abstracts

Introduction: With the improved imaging techniques, Leydig cell tumours (LCTs) are frequently found, accounting up to 22% of testicular tumours. The natural history of LCTs is relatively unknown, because of the small size and heterogeneity of available studies. Since LCTs are often removed, long-term follow-up is missing. The aim of this study was to report the experience with a large cohort of prospectively collected LCTs.Materials and methods: Patients...

Introduction: Differentiated thyroid cancer (DTC) is one of the most frequent forms of malignancy. Because of its favourable outcome and low mortality rates, identifying prognostic factors has been a challenge. Several risk stratification systems have been developed. Most of them include demographic and tumour specific features, as well as extrathyroidal extension. Our objective was to compare clinical characteristics between DTC patients with and without remission.<p clas...

Objectives: Pregnant women who are overweight or obese have an increased risk of complications during pregnancy, as do pregnant women with type 1 diabetes mellitus (DM1). The objective of this study is to describe the prevalence of overweight/obesity in pregnant women with DM1, and associated complications.Patients and methods: Retrospective descriptive study of pregnant women with DM1 (2004–2014). Variables analyzed: age, initial body mass index (B...

Background: Acromegaly is the consequence of excessive growth hormone (GH) secretion, usually produced by a pituitary adenoma. In the last years, statins have been implicated in the response to treatment of patients with acromegaly. Although this fact is not very clear.Objective: To analyze whether pretreatment with statins modifies the adenoma molecular phenotype of the acromegalic patients and how this changes could help to influence the response to tr...

Introduction: 46 XX testicular DSD (disorder of sex development) is a rare syndrome characterized by 46 XX karyotipe, male external genitalia, azoospermia, sterility and usually hypergonadotropic hypogonadism in adulthood. Approximately 85% of individuals present after puberty with normal penile size, small testes and gynecomastia.Case report: We present a 34-year-old male who was referred for endocrine evaluation due to slightly high prolactin levels. H...

Introduction: Resistance to thyroid hormone (RTH) is a rare autosomal dominant (AD) condition caused by mutations of the Thyroid Hormone Receptor Beta (TR-β) gene, resulting in generalized tissue resistance to thyroid hormone. Euthyroidism is usually maintained at the expense of increased levels of thyroid hormones and with non-supressed TSH.Case report: A 61 year-old-woman was evaluated for increased free T4 index: 2.29 ng/dl (normal, 0.9–2.1)...

Liver dysfunction related to hyperthyroidism encompasses abnormalities associated with the effects of thyroid hormone excess, drug-related hepatic injury, and the presence of concomitant liver disease. Mild liver abnormalities such as hypoalbuminemia and increased serum level of liver enzymes may be seen in 45–90% of patients with hyperthyroidism. Nevertheless, there are a few case reports of thyrotoxicosis associated with severe acute hepatitis. A 37 year old woman prese...

Introduction: Struma ovarii (SO) is a rare ovarian teratoma composed predominantly (more than 50%) or entirely of thyroid tissue. It constitutes 2% to 4% of ovarian teratomas. This tumor is often asymptomatic and discovered incidentally. Only 8% of patients present clinical hyperthyroidism.Case report: A 42-year-old woman presented palpitations, anxiety, sweating, emotional lability and weight loss for several months. Physical examination revealed goitre...

Background: Turner syndrome (TS) comprises a group of sex chromosome anomalies affecting approximately 15,000 in the UK. TS affects every organ system in the body through haploinsufficiency of genes that are normally expressed by both X chromosomes. Common features include short stature, congenital heart diease and gonadal dysgenesis requiring long-term oestrogen replacement but the adult phenotype extends to excess risk of diabetes, hypertension and hepatosteatosis. UCLH has ...

Introduction: Vitamin D insufficiency is very common among Spanish adults. It is well established there is an inverse relationship between vitamin D and PTH levels. The diagnostic approach of an increased serum PTH concentration in a normocalcemic normophosphatemic patient is frequent in routine practice and the deficiency of vitamin D is the major cause of secondary hyperparathyroidism (SHPT). The aims of this study were to evaluate the prevalence of SHPT in a cohort of normo...